Local Antimicrobial Delivery of Satranidazole Loaded Cross Linked Periodontal Chips Using Bio Degradable Polymers

Objective: The goal in using a local nonsurgical controlled intrapocket device for the delivery of an antimicrobial agent is the achievement and maintenance of therapeutic drug concentration for the desired period of time. Methods: The study was conducted to fabricate a bio erodible delivery system for Satranidazole, dispersed in two different polymers, natural Chitosan and semi synthetic HPMC polymers by simple casting method. The prepared chips were cross linked with glutaraldehyde 2 and 4 %v/v for 1, 2, 3 and 4 hours for extended release. Results: All chips prepared have good physicochemical properties .Static dissolution studies showed a burst release initially followed by a slow sustained release when cross-linking was attempted. The percentage cumulative drug release was greater in chitosan than HPMC. In vitro release and permeation Kinetics showed zero order profile. The cross linked formulations C52C3 and H52C1 are better than others because the extent of release was maintained for 8 and 6 days respectively. Histopathological studies of the periodontal mucosa suggested that the formulations were safe for local anti microbial treatment in to the infected periodontal pocket. The optimized formulation C52C3 showed highest mucosal permeation of Satranidazole and greater growth inhibition area for Porphyromonas gingivalis. Scanning electron microscopy showed that the upper surface of cross linked chips was smooth.The stability studies did not show any significant changes. Conclusion: The findings of the results easily predict the fact that chitosan and HPMC can be used to prepare chip utilizing the anti microbial property of Satranidazole for treating periodontitis.